Microsoft Defender AV must block untrusted and unsigned processes that run from USB.

Severity
Group ID
Group Title
Version
Rule ID
Date
STIG Version
mediumV-278649SRG-APP-000210WNDF-AV-000045SV-278649r1144034_rule2025-11-252
Description
This policy setting helps prevents unsigned or untrusted executable files from running from USB removable drives, including SD cards. Blocked file types include executable files (such as .exe, .dll, or .scr).
ℹ️ Check
Verify the policy value for Computer Configuration >> Administrative Templates >> Windows Components >> Microsoft Defender Antivirus >> Microsoft Defender Exploit Guard >> Attack Surface Reduction >> Configure Attack Surface Reduction rules is set to "Enabled". Procedure: Use the Windows Registry Editor to navigate to the following key: HKLM\Software\Policies\Microsoft\Windows Defender\Windows Defender Exploit Guard\ASR\Rules Criteria: If the value "b2b3f03d-6a65-4f7b-a9c7-1c7ef74a9ba4" is REG_SZ = 1, this is not a finding. If the value is other than 1, this is a finding.
✔️ Fix
Set the policy value for Computer Configuration >> Administrative Templates >> Windows Components >> Microsoft Defender Antivirus >> Microsoft Defender Exploit Guard >> Attack Surface Reduction >> Configure Attack Surface Reduction rules to "Enabled". Under the policy option "Set the state for each ASR rule:", then click "Show". Enter GUID "b2b3f03d-6a65-4f7b-a9c7-1c7ef74a9ba4" in the "Value Name" column. Enter "1" in the "Value" column. Click "OK". Click "Apply".