Microsoft Defender AV must scan packed executables.

This policy setting manages whether Microsoft Defender Antivirus scans packed executables. Packed executables are executable files that contain compressed code.

Verify the policy value for Computer Configuration >> Administrative Templates >> Windows Components >> Microsoft Defender Antivirus >> Scan >> Scan packed executables is set to "Enabled"; otherwise, this is a finding. Procedure: Use the Windows Registry Editor to navigate to the following key: HKLM\Software\Policies\Microsoft\Windows Defender\Scan Criteria: If the value "DisablePackedExeScanning" is REG_DWORD = 0, this is not a finding. If the value is 1, this is a finding.

Set the policy value for Computer Configuration >> Administrative Templates >> Windows Components >> Microsoft Defender Antivirus >> Scan >> Scan packed executables to "Enabled".